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目的 探讨血清转化生长因子 - β1 (TGF- β1 )在急性脑梗死 (ACI)发病过程中的变化及其意义。方法 采用酶联免疫吸附试验动态检测 35例 ACI患者血清 TGF- β1 浓度 ,分析其与梗死部位、大小、病情的相关性。结果 ACI患者血清 TGF- β1 浓度急性期降低 ,恢复期升高。皮质梗死组 TGF- β1 高于皮质下组 (P<0 .0 5 ) ;梗死体积大则 TGF- β1 浓度高 (P<0 .0 5 ) ;重型组 TGF- β1 浓度高于轻型组 ,但无统计学意义。梗死组中白细胞和单核细胞数高于对照组 (P<0 .0 5 )。结论 血清 TGF- β1 的产生与外周血白细胞总数有关 ,其浓度的改变与梗死部位、大小及病程有一定关系 ,提示 TGF- β1 是一种负性免疫调节剂。
Objective To investigate the changes of serum transforming growth factor-β1 (TGF-β1) in the pathogenesis of acute cerebral infarction (ACI) and its significance. Methods Serum levels of TGF-β1 in 35 patients with ACI were detected by enzyme-linked immunosorbent assay (ELISA), and their correlations with infarct size, size and disease were analyzed. Results Serum levels of TGF-β1 in patients with ACI were decreased in acute phase and increased in recovery phase. TGF-β1 in cortical infarction group was higher than that in subcortical group (P <0.05); TGF-β1 concentration was higher in infarct volume than that in light group (P <0.05) No statistical significance. The number of leukocytes and monocytes in infarction group was higher than that in control group (P <0.05). Conclusion The production of TGF-β1 is related to the total number of peripheral blood leukocytes. The change of concentration of TGF-β1 is related to the location, size and course of infarction. It indicates that TGF-β1 is a negative immunomodulator.