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肝细胞性肝癌(HCC)占我国癌症死亡的第2位。原发性肝细胞癌的产生是一个多因素参与,多步骤发生的过程。其中乙型肝炎病毒的感染为其最主要的危险因素。本文结合文献,围绕肝细胞癌分子遗传学几个焦点问题进行讨论,并探讨HCC发生的可能模式。
Hepatocellular carcinoma (HCC) accounts for the second cancer death in China. The occurrence of primary hepatocellular carcinoma is a multi-factor involved, multi-step process. Hepatitis B virus infection is the most important risk factor. This article combines the literature, focusing on several key issues of molecular genetics of hepatocellular carcinoma to discuss and explore possible patterns of HCC.