用免疫组织化学染色方法检测了慢性乙肝患者肝组织内C erbB 2、FAS蛋白的表达 ,发现这两种蛋白有较高的阳性检出率。这些在肝细胞膜表达的蛋白质与肝细胞周围的淋巴细胞浸润有密切的关系 ,而且在碎屑样坏死灶周围有较强的表达。提示乙肝病毒可激发一些内源性基因的异常表达 ,诱导肝细胞的凋亡和坏死 ,参与对肝细胞的免疫损害。 Immunohistochemical staining was used to detect the expression of C erbB 2 and FAS protein in the liver tissue of patients with chronic hepatitis B and found that the two proteins had higher positive detection rate. These proteins expressed in the liver cell membrane are closely related to the infiltration of lymphocytes around the liver cells and are more expressed around the debris-like necrosis. Prompt hepatitis B virus can stimulate the abnormal expression of some endogenous genes, induce apoptosis and necrosis of hepatocytes, and participate in the immune damage to hepatocytes.