隐球菌病大部分原发于肺部,常常播及脑膜和脑实质.播散性隐球菌病偶可累及皮肤.原发性皮肤隐球菌病是指皮肤损害是其唯一的表现,而无系统性或脑脊液的侵犯.本病较为罕见,可以在含有新型隐球菌的异物损伤皮下以后而出现.作者报告一例男性患者,81岁,因左前臂红肿痛一个月而就诊.查局部红肿湿润,渗出少量脓液,近卫淋巴结不大.给予红霉素治疗无效,且损害继续扩大,以至形成10×6.5cm溃疡.检查肺、神经系统及其他系统无异常.溃疡区活检表现为慢性炎症,可见多数淋巴细胞、组织细胞和少数多形核白细胞浸润.有多数胶样厚荚膜孢子,偶见巨细胞.溃疡组织在沙氏葡萄糖琼脂培养为新型隐球菌生长.此时作痰、尿、脑脊液直接镜检和培养均为阴性.遂 Cryptococcosis most of the primary in the lungs, and often spread to the meninges and brain parenchyma .Displastic cryptococcosis occasionally involving the skin.Primary cutaneous cryptococcosis is the only manifestation of skin damage, and no system Sexual or cerebrospinal fluid invasion of the disease is relatively rare, can contain Cryptococcus neoformans foreign body damage after subcutaneous appear .A report of a male patient, aged 81, due to left forearm swelling and pain for a month and treatment .Check local swelling and moist, Exudate a small amount of pus, lymph nodes near guard is not given to erythromycin invalid treatment, and the damage continues to expand, as well as the formation of 10 × 6.5cm ulcer.Check the lungs, nervous system and other systems without abnormal biopsy showed ulceration chronic inflammation , Showing the majority of lymphocytes, tissue cells and infiltration of a small number of polymorphonuclear leukocytes.Most gum samples thick capsule capsular spores, occasionally giant cells.Urinary ulcer tissue culture in sand dextrose agar for the growth of Cryptococcus neoformans.At this time for sputum, urine , Cerebrospinal fluid direct microscopy and culture were negative