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目的探讨胃癌组织Tiam1在胃癌的发生、发展过程中的作用。方法运用免疫组化法结合组织芯片技术联合检测189例胃癌、54例癌旁、30例正常组织及59例对应的淋巴结中的Tiam1蛋白表达情况。结果 Tiam1蛋白在胃癌组织、癌旁组织及正常胃黏膜的表达阳性率分别为85.7%、74.1%和16.7%,比较差异有统计学意义(χ2=67.448,P<0.001)。Tiam1蛋白表达与淋巴结转移、分化程度及浸润深度密切相关(P<0.05)。胃癌原发灶Tiam1蛋白表达阳性率(85.0%)高于相对应的淋巴结转移灶(65.0%)(χ2=4.267,P<0.05)。Tiam1蛋白表达阳性具有显著的生存危险,是独立的生存期预测因子。结论 Tiam1蛋白表达与临床病理特征密切相关,其表达方式与患者的生存期密切相关,可作为独立的生存期预测因子。
Objective To investigate the role of Tiam1 in gastric carcinogenesis and development. Methods Tissue microarray was used to detect the expression of Tiam1 protein in 189 cases of gastric cancer, 54 cases of adjacent normal tissues, 30 cases of normal tissues and 59 cases of corresponding lymph nodes. Results The positive rates of Tiam1 protein in gastric cancer tissues, paracancerous tissues and normal gastric mucosa were 85.7%, 74.1% and 16.7%, respectively, with significant difference (χ2 = 67.448, P <0.001). Tiam1 protein expression and lymph node metastasis, the degree of differentiation and depth of invasion are closely related (P <0.05). The positive rate of Tiam1 protein in primary gastric cancer (85.0%) was higher than that in corresponding lymph node metastasis (65.0%) (χ2 = 4.267, P <0.05). Positive expression of Tiam1 protein has a significant risk of survival and is an independent predictor of survival. Conclusion The expression of Tiam1 protein is closely related to the clinicopathological features. The expression pattern of Tiam1 is closely related to the survival of patients and may serve as an independent predictor of survival.