1640年Otani和Lichtein描述由组织细胞增生引起的骨损害一病,并命名为“骨嗜酸性肉芽肿”,由于本病容易和骨髓炎、骨结核等骨病相混淆,不少医生对本病的诊断和治疗经验不足,所以很难估计它的发病率。骨嗜酸性肉芽肿并非一种局限性病变,由于组织细胞的异常增殖,除骨骼受累外,也可侵犯肺、肝、脾、淋巴结和皮肤等其他 In 1640, Otani and Lichtein described a disease of bone damage caused by histiocytosis and named it “bone eosinophilic granuloma.” Because the disease is easily confused with bone diseases such as osteomyelitis and bone tuberculosis, many doctors are not familiar with this disease Lack of experience in diagnosis and treatment, it is difficult to estimate its incidence. Bone eosinophilic granuloma is not a localized disease, due to the abnormal proliferation of tissue cells, in addition to bone involvement, but also violations of lung, liver, spleen, lymph nodes and other skin