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根据细胞动力学、血管生成程度、p53肿瘤基因表达以及其它和肿瘤转移有关的分子机理的研究,就与侵犯肺尖的非小细胞肺癌(NSCLC)局部侵袭行为与治疗失败有关的生物学基础进行了研究。 接受根治手术治疗、侵犯肺尖的NSCLC28例,男25例,女3例,年龄36～73(平均56)岁。鳞癌10例,腺癌和大细胞癌各8例,混合细胞癌2例,采用鼠单克隆抗体以生物素过氧化酶法对切片进行免疫组化染色,对Ⅷ因子相关抗
Based on the study of cellular dynamics, angiogenesis, p53 tumor gene expression, and other molecular mechanisms involved in tumor metastasis, the biological basis associated with local invasive behavior and treatment failure in non-small cell lung cancer (NSCLC) invading the apex of the lung was investigated. Research. Twenty-eight cases of NSCLC who underwent radical surgery and invaded the apex were 25 males and 3 females, aged 36-73 years (mean 56 years). 10 cases of squamous cell carcinoma, 8 cases of adenocarcinoma and large cell carcinoma, and 2 cases of mixed cell carcinoma. Immunohistochemical staining of the sections using biotin peroxidase method using murine monoclonal antibody.