从当归中分离得到的具有增加血流量的活性成分8-甲氧基补骨脂内酯(1),服用后在体内几乎全部被代谢。由此推测,化合物1增加血流量的作用与其代谢物有关。此次比较探讨了静脉给予化合物1及其代谢物后对小鼠外周血流量的影响。方法及结果：对倍他米松(1．6 mg/kg,im)诱发血瘀证的小鼠iv给予化合物1及其代谢物后,检测背部的外周血流量。化合物1在0．046 mmol/kg The 8-methoxystostatin (1), which is an active ingredient with an increased blood flow isolated from Angelica sinensis, is almost completely metabolized in the body after administration. It is speculated that the effect of Compound 1 on increasing blood flow is related to its metabolites. This comparison explored the effect of intravenous administration of Compound 1 and its metabolites on peripheral blood flow in mice. METHODS AND RESULTS: Peripheral blood flow on the back was measured after iv administration of compound 1 and its metabolites to mice with blood stasis syndrome induced by betamethasone (1.6 mg/kg, im). Compound 1 at 0.046 mmol/kg