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目的研究和分析艾滋病病毒即人类免疫缺陷病毒(HIV-1)的耐药性及其主要的影响因素。方法 282例艾滋病患者,根据是否接受抗病毒治疗将其分为实验组(进行艾滋病HIV-1抗病毒治疗,157例)和对照组(未进行艾滋病HIV-1抗病毒治疗,125例),使用横断面的调查方法与基因型分析法,针对两组感染者分别进行耐药性检测,并将结果进行对比。结果共对两组中病毒载量(VL)在1000 copies/ml以上的110例聚合酶链式反应(PCR)呈现阳性的患者进行了耐药检测。实验组患者的耐药率为56.4%,显著地高于对照组15.5%,两组患者耐药率对比,差异具有统计学意义(P<0.01)。结论发生基因突变是使艾滋病病毒HIV产生耐药性的最主要的原因,进行艾滋病HIV-1抗病毒治疗的患者耐药率较高,应该引起足够的重视。
Objective To study and analyze the drug resistance of HIV-1, human immunodeficiency virus (HIV-1) and its main influential factors. Methods A total of 282 AIDS patients were divided into experimental group (157 cases with HIV-1 anti-virus treatment) and control group (125 cases without HIV-1 anti-virus treatment) according to whether they received antiviral therapy or not. Cross-sectional survey method and genotypic analysis, for two groups of infected were tested for drug resistance, and the results were compared. Results A total of 110 cases of patients with positive polymerase chain reaction (PCR) with a viral load (VL) above 1000 copies / ml in both groups were tested for drug resistance. The drug resistance rate in the experimental group was 56.4%, significantly higher than that in the control group (15.5%). There was significant difference in the drug resistance rate between the two groups (P <0.01). Conclusion Gene mutation is the most important reason to make HIV HIV drug-resistant, and HIV-1 HIV-infected patients should be given more attention.