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目的:了解糖尿病与结直肠癌患病的关系,明确糖尿病史对结直肠癌发病的影响,为做好结直肠癌的一级预防提供思路。方法:采用病例对照的方法分析同时期住院的结直肠癌(364例)及非肿瘤患者(733例)与糖尿病相关因素的关系及差异。对比分析两组患者的糖尿病史、糖尿病家族史、并发病情况、吸烟、饮酒等生活行为以及血脂水平等方面的差异。结果:结直肠癌组糖尿病患者患结直肠癌的危险度是非糖尿病患者的1.72倍,有糖尿病家族史者患结直肠癌的危险度也明显增加(OR值为1.64);多因素回归分析显示年龄、性别、糖尿病家族史、冠心病、高血压、吸烟、饮酒及血脂未进入方程,对结直肠癌未见显著影响;糖尿病史对结直肠癌患病具有显著影响。结论:糖尿病与结直肠癌患病存在一定的相关性,糖尿病增加了患结直肠癌的风险性,是结直肠癌患病的独立危险因素。
Objective: To understand the relationship between diabetes and colorectal cancer, clear the history of diabetes on the incidence of colorectal cancer, to provide a primary prevention for colorectal cancer provide ideas. Methods: The case-control method was used to analyze the relationship and differences between diabetes-related factors and colorectal cancer (364 cases) and non-cancerous patients (733 cases) hospitalized in the same period. Comparative analysis of two groups of patients with diabetes history, family history of diabetes, and incidence, smoking, drinking and other living behavior and blood lipid levels and other differences. Results: The risk of colorectal cancer in patients with colorectal cancer was 1.72 times that of patients without diabetes, and the risk of having colorectal cancer with family history of diabetes was significantly increased (OR = 1.64). Multivariate regression analysis showed that age , Gender, family history of diabetes, coronary heart disease, hypertension, smoking, drinking and blood lipid did not enter the equation, and had no significant effect on colorectal cancer. The history of diabetes had a significant effect on the prevalence of colorectal cancer. Conclusion: There is a correlation between diabetes and colorectal cancer. Diabetes increased the risk of colorectal cancer and was an independent risk factor for colorectal cancer.