论文部分内容阅读
目的 :研究颅脑肿瘤的磁共振质子波谱 (1HMRS)的表现及其临床鉴别诊断价值。 方法 :6 0例行1HMRS检查的不同组织类型来源颅脑肿瘤患者 ,术后均经病理明确诊断 ,观察和测量肿瘤和对侧正常组织的N 乙酰天冬氨酸 (NAA)、肌酐 (Cr)、胆碱 (Cho)、乳酸 脂质 (Lac Lip)峰值 ,计算肿瘤NAA/Cr、Cho/Cr、NAA/Cho以及肿瘤NAA/正常NAA、肿瘤Cho/正常Cho、肿瘤Cr/正常Cr的比率。 结果 :颅脑肿瘤Cr下降 ,Cho升高 ,但不同组织类型肿瘤的Cr、Cho变化无显著差异。脑肿瘤NAA下降明显 ,其中不同组织类型中脑膜瘤、胶质瘤、淋巴瘤相比变化无显著差异 ,但均明显低于听神经瘤和转移瘤 (P <0 .0 5 )。胶质瘤的NAA/Cr明显低于转移瘤和听神经瘤 ,P值分别为 0 .0 14、0 .0 2 7。各肿瘤的Cho/Cr无显著差异。 结论 :1HMRS是研究肿瘤代谢的有效方法 ,肿瘤NAA/正常NAA、NAA/Cr有助于颅脑肿瘤的诊断和鉴别诊断
Objective: To study the performance of magnetic resonance spectroscopy (1HMRS) in brain tumor and its clinical value in differential diagnosis. Methods: Totally 60 patients with craniocerebral tumor who had different histological types from 1HMRS were diagnosed by histopathology. The contents of N-acetyl-aspartate (NAA) and creatinine (Cr) in tumor and contralateral normal tissue were observed and measured. The ratio of tumor NAA / Cr, Cho / Cr, NAA / Cho and tumor NAA / normal NAA, tumor Cho / normal Cho, tumor Cr / normal Cr were calculated. Results: Cr in brain tumors decreased and Cho increased. However, there was no significant difference in Cr and Cho between different types of tumors. NAA decreased significantly in brain tumors. There was no significant difference in the changes of NAA, glioma and lymphoma among different types of brain tumors, but both were significantly lower than those of acoustic neuroma and metastases (P <0.05). NAA / Cr in gliomas was significantly lower than that in metastases and acoustic neuromas, with P values of 0.014, 0.027, respectively. Cho / Cr of each tumor showed no significant difference. Conclusion: 1HMRS is an effective method to study tumor metabolism. Tumor NAA / normal NAA and NAA / Cr contribute to the diagnosis and differential diagnosis of brain tumors