目的 探讨颅底肿瘤的手术进路。方法 采用经口半侧Lefort Ⅰ型截骨途径切除颅底巨大脊索瘤。结果 该手术进路避免了气管切开及下颌正中切开， 且面部不留疤痕， 手术视野清楚， 术后不影响咀嚼功能等优点。结论 经口半侧Lefort Ⅰ型截骨途径可用于切除颅底肿瘤。 Objective To explore the surgical approach of skull base tumor. Methods Oral half Lefort Ⅰ osteotomy approach was used to excise the giant skull base tumor. Results The surgical approach to avoid tracheotomy and mandibular incision, and the face without leaving scars, clear vision of the operation, postoperative does not affect the chewing function and so on. Conclusion Oral half-Lefort Ⅰ osteotomy approach can be used to excise the skull base tumors.