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文章选取缺血性心肌病患者和对照组收集的外周血,对其采用微阵列数据集进行转录组分析,分为两个部分进行。在第一部分,从3组缺血性心肌病患者样本与健康对照的数据集分析中,确定了3个重要基因——成纤维细胞生长因子结合蛋白2(FGFBP2)、葡萄糖-果糖氧化还原酶结构域(GFOD1)和伴皮层下囊肿的巨脑性白质脑病(MLC1),可作为潜在的m RNA生物标志物。在第二部分,从3个时间点(发作当天、恢复4~6天及恢复6个月)收集了2组基因表达数据集。基因代谢途径的差异性分析表明,与对照组对比,发作组和恢复组涉及到炎症和免疫途径;与恢复6个月组对比,发作组和恢复组(4~6天)涉及到代谢途径或神经分泌。这显示了缺血性心肌病的发作和恢复期间的生物学过程变化。实验结果表明,3种潜在的m RNA生物标志物——FGFBP2、GFOD1和MLC1,涉及到缺血性心肌病不同的代谢通路,具有连续的生物学过程变化。
In this study, peripheral blood collected from patients with ischemic cardiomyopathy and control group was selected and analyzed by transcriptome using microarray dataset. The analysis was divided into two parts. In the first part, from the dataset analysis of three groups of patients with ischemic cardiomyopathy and healthy controls, three important genes, fibroblast growth factor binding protein 2 (FGFBP2), glucose-fructose oxidoreductase structure Domain (GFOD1) and meningocele associated with subcortical cystoid encephalopathy (MLC1), may serve as potential m RNA biomarkers. In the second part, two sets of gene expression datasets were collected from 3 time points (4 to 6 days recovery and 6 months recovery). Differences in gene metabolic pathways showed that the attack and recovery groups involved inflammatory and immune pathways compared with the control group; the recovery and recovery groups (4 to 6 days) involved metabolic pathways or Nerve secretion. This shows the onset of ischemic cardiomyopathy and changes in the biological processes during recovery. The experimental results show that three potential m RNA biomarkers, FGFBP2, GFOD1 and MLC1, involve different metabolic pathways of ischemic cardiomyopathy and have continuous biological process changes.