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目的研究河南省某县人类免疫缺陷病毒(HIV)/艾滋病(AIDS)患者合并丙型肝炎病毒(HCV)及CD4+T淋巴细胞数、病毒载量、机会性感染情况。方法采用整群抽样方法调查383名既往艾滋病感染者/病人,获得基线数据,1年后随访,分别进行病毒载量、CD4+T淋巴细胞数、肝功能及机会性感染检查。结果 383名HIV感染者中合并HCV者273人,占71.3%;2007年基线调查机会性感染率高的依次是肺部感染(27.2%)、发热(23.4%)、带状疱疹(13.7%)、腹泻(9.6%),2008年随访调查机会性感染率高的依次是肺部感染(21.9%)、发热(16.0%)、腹泻(14.9%)和带状疱疹(9.7%);谷丙转氨酶(ALT)、γ谷氨酶转肽酶(GGT)在基线和随访调查中的均数均明显高于正常参考范围。结论既往供血HIV感染人群中合并HCV的人较多;CD4+T细胞水平越低,机会性感染发生率越高,不同HIV病毒载量水平下机会性感染发生率差异无统计学意义。
Objective To study the relationship between hepatitis C virus (HCV) and CD4 + T lymphocyte count, viral load and opportunistic infection in HIV / AIDS patients in a county of Henan Province. Methods 383 former HIV / AIDS patients were surveyed by cluster sampling method. Baseline data were obtained and followed up one year later. The viral load, CD4 + T lymphocyte count, liver function and opportunistic infections were examined. Results Among the 383 HIV-infected patients, 273 were HCV-infected, accounting for 71.3%. The highest incidence of opportunistic infections in the baseline survey in 2007 were pulmonary infection (27.2%), fever (23.4%) and shingles (13.7%), (9.6%), diarrhea (14.9%) and shingles (9.7%). The rates of alanine aminotransferase ALT, GGT at baseline and follow-up were significantly higher than the normal reference range. CONCLUSIONS: In the past, there were more HCV co-infected patients in HIV-infected population. The lower the level of CD4 + T cells, the higher the incidence of opportunistic infections. There was no significant difference in the incidence of opportunistic infections among different HIV viral load groups.