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目的观察并探讨哮平方在防治小儿支气管哮喘方面的临床疗效及其对T淋巴细胞亚群数值的影响。方法选择2009年2月至2011年2月期间在我院儿科病房收治的支气管哮喘患儿120例,随机平均分为研究组和对照组,研究组(60例)采用哮平方治疗,对照组(60例)采用玉屏风颗粒治疗,疗程为3个月,治疗后观察两组的临床疗效,并检测治疗前后T淋巴细胞亚群数值的变化,并且与正常组的40例小儿对照。结果研究组的总有效率为96.7%,明显高于对照组的(76.7%)(P<0.05)。两组在治疗前外周血CD3、CD4以及CD8均低于正常组(P>0.05),CD4/CD8的比值也均低于正常组(P>0.05);研究组治疗后CD3、CD4以及CD8的水平较治疗前有明显改善(P<0.05);治疗后研究组与对照组相比,CD3、CD4以及CD4/CD8均有显著差异(P<0.05);研究组治疗后与正常组相比,CD3、CD4以及CD8均趋于正常数值。结论哮平方能显著改善小儿支气管哮喘的临床症状,降低了哮喘发作的频率,疗效确切,并且具有调节免疫功能的作用。
Objective To observe and explore the clinical efficacy of Asthma Prescription in the prevention and treatment of pediatric bronchial asthma and its effect on the number of T lymphocyte subsets. Methods 120 cases of bronchial asthma admitted to pediatric ward in our hospital from February 2009 to February 2011 were randomly divided equally into study group and control group. The study group (60 cases) 60 cases) treated with Yupingfeng granule for 3 months. After treatment, the clinical curative effect of the two groups was observed. The changes of T lymphocyte subsets before and after treatment were also measured, and compared with 40 cases in normal group. Results The total effective rate of the study group was 96.7%, which was significantly higher than that of the control group (76.7%) (P <0.05). The levels of CD3, CD4 and CD8 in the peripheral blood of the two groups before treatment were lower than those of the normal group (P> 0.05) and the ratios of CD4 / CD8 were also lower than those of the normal group (P> 0.05) (P <0.05). Compared with the control group, the levels of CD3, CD4 and CD4 / CD8 in the study group were significantly different (P <0.05). Compared with the normal group, CD3, CD4 and CD8 tend to normal values. Conclusion Asthma can significantly improve the clinical symptoms of bronchial asthma in children, reducing the frequency of asthma attacks, the exact effect, and has the role of immune regulation.