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目的 :建立简单实用的大鼠脑震荡动物模型 ,为其损伤规律和机制的研究奠定基础。方法 :采用自制装置 ,分别利用不同重量 (2 0 0g,10 0g和 5 0g)砝码 ,从 1m高度对大鼠造成脑损伤 ,选择合适的砝码重量制作脑震荡动物模型 ,动态观察伤后大鼠意识状态、行为学及病理学变化。结果 :大鼠受到撞击后 ,呈现典型的“先昏迷再清醒”的脑震荡临床表现 ,病理学显示顶枕部、额叶、颞叶出血 ,迷宫实验显示其学习记忆能力下降。结论 :该装置较好地复制了脑震荡模型 ,且与临床上造成脑震荡的表现相似 ,有助于进行不同程度脑损伤后继发病理生理变化的机制和相应的治疗研究。
Objective: To establish a simple and practical animal model of rat concussion and lay a foundation for the study of its injury mechanism and mechanism. Methods: Using self-made devices, different weights (200g, 100g and 500g) were used to induce brain injury from 1m height. The animal model of concussion was selected by appropriate weight to dynamically observe the injury Rats’ state of consciousness, behavior and pathology. Results: After shocked, the rats presented typical clinical manifestations of “first coma and then awake” concussion. Pathology showed the top occipital lobe, frontal lobe and temporal lobe hemorrhage. The maze test showed that the ability of learning and memory decreased. CONCLUSION: This device replicates the concussion model well, and it is similar to the clinical manifestation of concussion. It is helpful for the mechanism of secondary pathophysiological changes after different degrees of brain injury and corresponding treatment research.