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目的探讨在男性增龄过程中几种钙调节激素和体重指数(BMI)与骨量的关系。方法426例30～80岁的健康男性采用双能x线骨密度仪检测腰椎、髋部、前臂骨密度(BMD)值,与正常人群峰值骨密度值比较的标准差形成T评分,同时对其中160例人群测定睾酮(T)、降钙素(CT)、甲状旁腺素(全段PTH SP)、总三碘甲腺原氨酸(T3)、总甲状腺素(T4)、骨钙素(BGP),观察各年龄组骨量变化规律并与BMI、钙调节激素进行相关性分析。结果骨量随增龄逐渐下降,各部位方差分析差异有显著性;骨密度(Ward三角)与年龄显著负相关(P<0.001),与BMI、T显著正相关(P<0.001,P<0.05),逐步回归分析显示与BMI和T相关。结论BMI和T是男性增龄过程中影响骨量的主要因素。
Objective To investigate the relationship between several calcium-regulated hormones and body mass index (BMI) and bone mass in men during aging. Methods 426 healthy men aged 30 to 80 years old were used to detect the bone mineral density (BMD) of the lumbar spine, hip and forearm by dual-energy x-ray absorptiometry. The standard deviation of peak bone mineral density (BMD) 160 patients were tested for the levels of testosterone, calcitonin, parathyroid hormone (PTH SP), total triiodothyronine (T3), total thyroxine (T4), osteocalcin BGP). The changes of bone mass in each age group were observed and analyzed with correlations between BMI and calcium-regulated hormones. Results The bone mineral density decreased gradually with age, and there was significant difference in ANOVA among all the groups. There was a significant negative correlation between BMD (Ward Triangle) and age (P <0.001) and BMI and T (P <0.001, P <0.05) ), Stepwise regression analysis showed that BMI and T related. Conclusion BMI and T are the main factors affecting the bone mass in the aging process of men.