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以壳聚糖-甘油磷酸钠-柠檬酸溶液为液相,制备了一种新型可注射的硼酸盐玻璃骨水泥,通过维卡仪、万能试验机、XRD、FTIR、SEM-EDS等探究了液相中柠檬酸浓度(0.1,0.2和0.4 g/m L)对硼酸盐玻璃骨水泥性能的影响。结果表明:柠檬酸浓度显著影响骨水泥的凝结时间和可注射性。柠檬酸浓度为0.2 g/m L时获得的骨水泥的凝结时间最短,为(16±0.5)min;可注射性最好,接近100%。骨水泥压缩强度随柠檬酸浓度增大而增强,最大可达(26.7±1.9)MPa。SEM照片显示骨水泥中生成了许多纳米微粒。XRD、FTIR和EDS等结果证明,这些纳米微粒主要是硼酸盐、磷酸盐和柠檬酸盐等物质,而且柠檬酸浓度能够影响骨水泥中硼酸盐晶体的形成。此外,柠檬酸能够加速玻璃颗粒在磷酸钠盐缓冲液中的降解速率。
A new type of injectable borate glass bone cement was prepared by using chitosan-glycerophosphate-citric acid solution as the liquid phase, and investigated by Vicat apparatus, universal testing machine, XRD, FTIR and SEM-EDS Effect of Citric Acid Concentration (0.1, 0.2 and 0.4 g / m L) in Liquid Phase on the Properties of Borate Glass Bone Cements. The results showed that citric acid concentration significantly affected the setting time and injectability of bone cement. The setting time of bone cement obtained with citric acid concentration of 0.2 g / m L was the shortest (16 ± 0.5) min; the best injectability was close to 100%. The compressive strength of bone cement increased with the increase of citric acid concentration up to (26.7 ± 1.9) MPa. SEM images showed that many nanoparticles were produced in the bone cement. The results of XRD, FTIR and EDS show that these nanoparticles are mainly borate, phosphate and citrate, and citrate concentration can influence the formation of borate crystals in bone cement. In addition, citric acid accelerates the rate of glass particles degradation in sodium phosphate buffer.