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血管内皮生长因子(Vacularendothelial growth factor,VEGF)-血管内皮生长因子受体-2(VEGF receptor2,VEGFR-2)信号轴调控血管生成反应。糖尿病病理状态下,氧化应激异常激活、NO等血管活性物质功能受损、以及晚期糖基化终末产物增加,该信号轴功能失调,使得血管生成反应在一些器官组织中呈增强状态,如视网膜和肾;然而在另一些组织中却是受到抑制,如外周血管等。不正常的血管生成反应最终导致糖尿病性心血管并发症的发生。因此,阐明血管生产反应功能障碍,将为糖尿病心血管并发症靶向治疗提供依据。
Vascular endothelial growth factor (VEGF) - vascular endothelial growth factor receptor - 2 (VEGFR - 2) signaling axis regulates angiogenesis. Diabetic pathology, abnormal activation of oxidative stress, NO and other vasoactive substances impaired function, and advanced glycation end products increased, the signal axis dysfunction, making angiogenic reactions in some organs and tissues showed an enhanced state, such as Retina and kidney; however, it is inhibited in other tissues, such as peripheral blood vessels. Abnormal angiogenic reactions eventually lead to the development of diabetic cardiovascular complications. Therefore, to clarify the dysfunction of vascular production response, will provide the basis for targeted therapy of diabetic cardiovascular complications.