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目的:观察尼莫地平(NMD)治疗脑梗死的疗效。方法:将120例脑梗死入选病例随机分为治疗组和对照组各60例,2组患者均给予常规治疗,使用脱水、神经营养、活血化瘀、降压、调脂、降糖及对症治疗,治疗组在此基础上口服NMD30mg,tid。疗程均为15d。观察2组疗效,治疗前与治疗15d后进行神经功能缺损评分,并行经颅多普勒彩超检测血液流变学改变。结果:治疗组的总有效率为86.7%,明显高于对照组的总有效率(60.0%),2组比较差异有统计学意义(P<0.05);治疗组治疗前、后及2组简易精神状态检查量表(MMSE)、中国卒中量表(CSS)、巴氏指数(BI)评分比较差异均有统计学意义(P<0.05);对照组治疗前、后MMSE评分比较差异有统计学意义(P<0.05);治疗组1个月后的大脑中动脉、前动脉及后动脉的血流速度较治疗前明显增加,且较对照组增加明显,2组比较差异均有统计学意义(P<0.01);2组均未见严重不良反应。结论:NMD治疗脑梗死疗效显著,神经功能恢复好,脑血流量增加更明显,安全性好。
Objective: To observe the effect of nimodipine (NMD) on cerebral infarction. Methods: 120 cases of cerebral infarction were randomly divided into treatment group and control group of 60 cases, two groups were given routine treatment, the use of dehydration, neurotrophic, blood circulation, blood pressure, lipid-lowering, hypoglycemic and symptomatic treatment , The treatment group on the basis of oral NMD30mg, tid. Treatment are 15d. The curative effect of the two groups were observed. The neurological deficit scores were measured before treatment and after 15 days of treatment. Transcranial Doppler echocardiography was used to detect the changes of hemorheology. Results: The total effective rate of the treatment group was 86.7%, which was significantly higher than that of the control group (60.0%). The difference between the two groups was statistically significant (P <0.05) MMSE, CSS and BI scores were significantly different (P <0.05). There were significant differences in MMSE scores before and after treatment in the control group (P <0.05). After 1 month, the blood flow velocity of middle cerebral artery, anterior and posterior arteries of the treatment group increased significantly compared with that before treatment, and increased significantly compared with the control group (P <0.05). There was significant difference between the two groups P <0.01). No serious adverse reactions were found in the two groups. Conclusion: NMD treatment of cerebral infarction significant effect, good neurological recovery, more significant increase in cerebral blood flow, good safety.