对荧光涂料１４７Ｐｍ内照射人淋巴细胞白血病细胞株Ｍｏｌｔ－４细胞和巨噬细胞株ＡＮＡ－１细胞诱发细胞凋亡进行了研究。估算了１４７Ｐｍ在不同阶段培养细胞中的辐射累积吸收剂量。通过荧光显微镜的形态观察，发现免疫细胞Ｍｌｔ－４和ＡＮＡ－１细胞在受１４７Ｐｍ内照射作用后，可诱发明显的核断裂和核固缩，以及凋亡小体形成为特征的细胞凋亡。微观放射自显影研究表明，１４７Ｐｍ可通过免疫细胞膜，在细胞内呈亲膜性积聚，并在膜包裹的凋亡小体周围呈现。从而证明了１４７Ｐｍ内照射可导致免疫细胞Ｍｏｌｔ－４和ＡＮＡ－１细胞的凋亡发生。 Fluorescent coating 147Pm internal irradiation human lymphoblastic leukemia cell line Molt-4 cells and macrophage cell line ANA-1 cells induced apoptosis. The cumulative absorbed dose of 147 Pm in cultured cells at different stages was estimated. Fluorescence microscopy showed that Mlt-4 and ANA-1 cells could induce obvious nuclear breaks and nuclear pyknosis and apoptosis of apoptotic bodies when they were exposed to 147Pm. Micro-autoradiography studies show that 147Pm can pass through the immunocyte membrane, accumulate in the cells in a pro-membrane form, and appear around the membrane-wrapped apoptotic body. Thus it was demonstrated that 147Pm internal irradiation could lead to the apoptosis of Molt-4 and ANA-1 cells.