论文部分内容阅读
目的：探讨大剂量维生素Ｃ对急性颅脑伤的治疗效果。方法：以自由落体法致猫脑挫伤后分组静脉滴注维生素Ｃ（２００ｍｇ／ｋｇ）和地塞米松（５ｍｇ／ｋｇ），测定血浆和脑脊液中ＡＶＰ和Ｄｙｎ－Ａ含量的变化，对挫伤区脑组织进行光镜和电镜观察。结果：维生素Ｃ治疗组动物脑创伤区病理改变明显好于颅脑伤组，脑含水量、颅内压以及血浆和脑脊液中ＡＶＰ和Ｄｙｎ－Ａ的含量均显著低于颅脑伤组，与大剂量地塞米松组相比，脑含水量亦显著降低。结论：大剂量维生素Ｃ治疗急性颅脑伤与大剂量地塞米松治疗效果相当，而且在降低脑水肿方面优于地塞米松。
Objective: To investigate the therapeutic effect of high-dose vitamin C on acute craniocerebral injury. Methods: The contents of AVP and Dyn-A in plasma and cerebrospinal fluid (CSF) were measured by vitamin C (200mg / kg) and dexamethasone (5mg / kg) Tissue light microscopy and electron microscopy. Results: The pathological changes in traumatic brain of animals treated with vitamin C were significantly better than that of traumatic brain injury. The contents of brain water, intracranial pressure and AVP and Dyn-A in plasma and cerebrospinal fluid were significantly lower than those in traumatic brain injury group. Compared with the dexamethasone group, brain water content was also significantly reduced. Conclusion: The treatment of acute craniocerebral injury with high dose of vitamin C is equivalent to high dose dexamethasone treatment, and it is superior to dexamethasone in reducing cerebral edema.