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β-肾上腺素能受体阻滞剂对心绞痛、高血压和心律失常的疗效久已公认,但全面阻滞β-受体常伴有副作用。氨酰心安(Atenololo)是一种选择性β-阻滞剂,每日给药一次即有强力的抗心绞痛和抗高血压作用。本文评价氨酰心安长程治疗的临床价值,着重观察其抗心绞痛作用以及药物的血浆浓度、排泄途径和合适的剂量,并与短程疗效作比较。方法:12名临床诊断为稳定型运动诱发心绞痛的患者,病程均已超过三个月。先作2周氨酰心安剂量范围和效益的单盲试验,测定服用安慰剂时的各项参数作为对照值并调整每例的剂量为100毫克/日或200毫克/日。然后开始用氨酰心安作长程治疗,3例因故停止服药,余9例(6例男性和3例女性,平均年龄53岁)均服氨酰心安至少一年。氨酰心安的剂量为每日100或200毫克,一次服用,仅一例因治疗一个月后有疲乏,剂量减至每日50毫克。所有病人在一年中不再改动调整过的剂量。患
Beta-adrenergic blockers have long been recognized for the efficacy of angina pectoris, hypertension, and arrhythmia, but the general blocker of beta-receptors is often associated with side effects. Atenololol is a selective β-blocker that has potent anti-anginal and antihypertensive effects once daily. This article evaluates the clinical value of long-term treatment of atenolol, and focuses on its anti-anginal effect and its plasma concentration, excretion route and appropriate dosage, and compared with short-term efficacy. Methods: Twelve patients diagnosed as stable exercise-induced angina were over three months. A 2-week atenolol dose range and benefit of a single-blind trial, the determination of placebo when taking the various parameters as a control value and adjust the dose for each case of 100 mg / day or 200 mg / day. Then began with atenolol for long-term treatment, 3 patients stopped taking medication for some reason, the remaining 9 cases (6 males and 3 females, mean age 53 years) were treated with atenolol at least one year. Atenolol dose of 100 or 200 mg daily, taking once, only one case of fatigue after a month of treatment, the dose reduced to 50 mg daily. All patients will not change the adjusted dose in a year. Suffering