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目的观察奥曲肽联合奥美拉唑治疗肝炎后肝硬化并上消化道出血的临床效果。方法选取长葛市人民医院2011年9月至2013年9月收治的70例肝炎后肝硬化并上消化道出血患者,随机分为观察组与对照组,每组35例,观察组采用奥曲肽联合奥美拉唑治疗,对照组采用垂体后叶素联合奥美拉唑治疗,比较两组患者的临床疗效、止血时间及不良反应发生情况。结果观察组治疗总有效率为94.3%,对照组为74.3%,两组比较差异有统计学意义(P<0.05);观察组止血时间明显短于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论奥曲肽联合奥美拉唑治疗肝炎后肝硬化并上消化道出血效果显著,安全性高,值得推广应用。
Objective To observe the clinical effect of octreotide combined with omeprazole in the treatment of posthepatitic cirrhosis and upper gastrointestinal bleeding. Methods Seventy patients with posthepatitic cirrhosis and upper gastrointestinal hemorrhage who were treated in Changge People’s Hospital from September 2011 to September 2013 were randomly divided into observation group and control group with 35 cases in each group.The patients in observation group were treated with octreotide Omeprazole treatment, the control group with pituitrin combined with omeprazole treatment, the two groups of patients with clinical efficacy, bleeding time and adverse reactions. Results The total effective rate was 94.3% in the observation group and 74.3% in the control group, the difference between the two groups was statistically significant (P <0.05); the bleeding time in the observation group was significantly shorter than that in the control group (P <0.05) The incidence was no significant difference (P> 0.05). Conclusion Omeprazole combined with omeprazole in the treatment of posthepatitic cirrhosis and upper gastrointestinal bleeding is effective, safe and worthy of promotion.