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目的:探讨药源性心脏损害的特点及规律,为临床安全合理用药提供参考。方法:采用回顾性调查方法,对1994～2010年国内医药期刊报道的412例药物致心脏损害病例进行统计分析。结果:412例药源性心脏损害中,循环系统药物占30.58%,抗微生物药占14.81%。药源性心脏损害的临床表现主要为各种类型的心律失常,严重会导致心肌梗死、心衰、心跳骤停等。结论:临床要加强对药源性心脏损害的监测,减少不良反应的发生。
Objective: To investigate the characteristics and rules of drug-induced heart damage and provide reference for clinical safety and rational drug use. Methods: A retrospective survey was conducted to analyze the 412 cases of drug-induced heart damage reported by the domestic medical journals from 1994 to 2010. Results: In 412 cases of drug-induced cardiac damage, the circulatory system drugs accounted for 30.58% and antimicrobial drugs accounted for 14.81%. The clinical manifestations of drug-induced heart damage mainly for various types of arrhythmia, can lead to serious myocardial infarction, heart failure, cardiac arrest and so on. Conclusion: Clinical monitoring of drug-induced heart damage should be strengthened to reduce the incidence of adverse reactions.