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目的比较不同治疗方案对先天性卵巢发育不全症（Ｔｕｒｎｅｒ综合征，ＴＳ）患儿身高增长的疗效。方法回顾性分析两组ＴＳ患儿的疗效：一组（６例）接受小剂量康力龙治疗５～１６个月，另一组（１２例）接受同样剂量的康力龙与生长激素（ＧＨ）联合治疗６～１４个月。结果单用康力龙组生长速度（ＧＶ）达到（５５４±１４６）ｃｍ／ａ，身高Ｚ评分（ＨｔＳＤＳ）由－３９１±１３４提高到－３５３±１４３。联合治疗组生长速度为（８５３±２５７）ｃｍ／ａ，ＨｔＳＤＳ由－３３６±１１６提高到－２６１±１０４。联合治疗组疗效较单用康力龙组为优（Ｐ＜００５），其治疗期间ＧＶ与患儿年龄呈负相关（ｒ＝－０８０，Ｐ＜００１）。结论联合应用ＧＨ与小剂量康力龙治疗ＴＳ疗效确切，适宜临床应用。
Objective To compare the effects of different treatment regimens on the growth of children with congenital ovarian hypoplasia (Turner syndrome, TS). Methods The clinical effects of two groups of TS children were retrospectively analyzed: one group (6 cases) received low-dose quetiapine treatment for 5 to 16 months and the other group (12 cases) received the same dose of combination therapy of combina- tion of hilum citrate and growth hormone ~ 14 months. Results The growth rate (GV) in group KangLongLong was (5.54 ± 1.46) cm / a, and the height Z score was increased from -3.91 ± 1.34 to -3.53 ± 1.43. The growth rate of the combination therapy group was (8.53 ± 2.57) cm / a, and the HtSDS was increased from -3.36 ± 1.16 to -2.61 ± 1.04. The combination therapy group was better than the single use of Kang Lilong group (P <0 05), the treatment of GV was negatively correlated with the age of children (r = -080, P <0 01). Conclusions The combination of GH and low dose of Kang Lilong TS treatment is effective and suitable for clinical application.