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目的探讨胃安素对胃粘膜的保护作用。方法动物实验:将动物随机分为正常对照组、无水乙醇对照组及胃安素预防组。实验前禁食24h,禁水2h,分别以 N.S1ml,N.S1ml 及胃安素1ml 灌胃,2h 后再分别以 N.S1ml,无水乙醇1ml 及无水乙醇1ml 灌胃。再过2h 后麻醉,抽血,处死取胃。进行大体、光镜、电镜观察,检测胃粘膜Na~+ -K~+ -ATPase 活性、胃酸及血浆内皮素、前列腺素。临床研究:胃安素组及雷尼替丁组均为胃溃疡患者,分别口服胃安素30mg,雷尼替丁150mg,2次/d,共4周。治疗前及治疗后随访症状、体征、不良反应,并作血尿常规、肝肾功能及内镜检查。结果胃安素能增强胃粘膜 Na~+-K~+-ATPase 活力,增加胃粘膜前列腺素合成及降低血浆内皮素,但不影响胃酸分泌。胃安素组大鼠的胃粘膜损伤较无水乙醇组明显减轻。胃安素治疗胃溃疡的效果略优于雷尼替丁。结论胃安素有明显的胃粘膜保护作用。
Objective To investigate the protective effect of gasuan on gastric mucosa. Methods Animal experiments: The animals were randomly divided into normal control group, ethanol control group and Weinan prevention group. Fasting 24h before the experiment, water for 2h, respectively, N.S1ml, N.S1ml and gastric hormone 1ml orally, 2h and then were N.S1ml, ethanol and ethanol, 1ml 1ml gavage. After another 2h anesthesia, blood, sacrifice the stomach. The changes of Na ~ + -K ~ + -ATPase, gastric acid, plasma endothelin and prostaglandin in gastric mucosa were detected by light microscope and electron microscope. Clinical studies: Weinan group and ranitidine group were gastric ulcer patients, respectively, oral administration of stomach hormone Suanrentetin 150mg, 2 times / d, a total of 4 weeks. Before treatment and follow-up after treatment of symptoms, signs, adverse reactions, and for hematuria, liver and kidney function and endoscopy. Results Weinan can enhance gastric mucosal Na ~ + -K ~ + -ATPase activity, increase gastric mucosal prostaglandin synthesis and reduce plasma endothelin, but does not affect gastric acid secretion. Gastric mucosal lesion in the stomach An Su group was significantly reduced than that in the anhydrous ethanol group. Gastric hormone treatment of gastric ulcer slightly better than ranitidine. Conclusion Weinan has obvious gastric mucosal protective effect.