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目的：研究孕妇感染巨细胞病毒（ＣＭＶ）、弓形虫（ＴＯ）、细小病毒Ｂ１９与异常生育的关系。方法：应用ＰＣＲ方法检测实验组２０７例怀孕及有异常妊娠史妇女的血、宫颈分泌物，流产物和羊水中ＣＭＶ、ＴＯ和Ｂ１９ＤＮＡ；对照组２１０例正常孕妇检测宫颈分泌物中ＣＭＶ、ＴＯ和Ｂ１９ＤＮＡ。结果：实验组ＣＭＶ、ＴＯ和Ｂ１９ＤＮＡ阳性率分别为１６．９１％（３５／２０７），１１．１１％（２３／２０７），和９．１８％（１９／２０７）。对照组ＣＭＶ、ＴＯ和Ｂ１９ＤＮＡ阳性率分别为５．２４％（１１／２１０）、３．３３％（７／２１０）和１．９０％（４／２１０）。两组之间有十分显著差异（Ｐ＜０．０１）。结论：孕妇感染ＣＭＶ、ＴＯ和Ｂ１９与异常生育关系极为密切。
Objective: To study the relationship between pregnant women infected with cytomegalovirus (CMV), toxoplasma (TO), parvovirus B19 and abnormal fertility. Methods: PCR, the CMV, TO and B19 DNA in 207 pregnant women and women with abnormal pregnancy were detected in the blood, cervix, abortion and amniotic fluid in pregnant women. The control group of 210 pregnant women were tested for CMV, TO and B19 DNA. Results: The positive rates of CMV, TO and B19 DNA in experimental group were 16.91% (35/207), 11.11% (23/207) and 9.18% (19/207) respectively. The positive rates of CMV, TO and B19DNA in control group were 5.24% (11/210), 3.33% (7/210) and 1.90% (4/210) respectively. There was a significant difference between the two groups (P <0.01). Conclusion: Pregnant women infected with CMV, TO and B19 are closely related to abnormal fertility.