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本文报道检测8种致突变物/致癌物的致突变性。检测结果表明灭滴灵,呋喃西林和灭菌丹对→A1535,TA98和E.coliwp_2uvrA,呋喃唑酮(最大剂量0.65μg/平板)对AT98和E.coliwp_2uvrA有致突变效应,并且对E.coliwp_2uvrA每平板诱发的回变菌落数大大地超过TA1535和TA98。铬酸钾和咖啡因分别对E.coliwp_2和E.coliND-160诱发回复突变,而对TA1535,TA1537和TA98均无作用。非那西汀和氨基比林对两种细菌系统均不诱发回复突变体。我们认为应用大肠杆菌系统检测某些化学诱变剂有一定的优越性。
This article reports the detection of eight mutagens / carcinogens mutagenicity. The results showed that metronidazole, nitrofurazone and bacteriocin had a mutagenic effect on AT98 and E.coliwp_2uvrA at → A1535, TA98 and E.coliwp_2uvrA and furazolidone (maximum dose of 0.65 μg / plate) Replicate colonies greatly exceeded TA1535 and TA98. Potassium chromate and caffeine induced the reverse mutation in E.coliwp_2 and E.coli ND-160, respectively, but had no effect on TA1535, TA1537 and TA98. Phenacetin and aminopyrine did not induce a revertant on both bacterial systems. We think the use of E. coli system for the detection of certain chemical mutagens has some advantages.