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作者5年间对慢性乙肝病毒感染病人进行回顾性和前瞻性相结合的研究。根据其临床、生化和血清学变化,评价其血清乙肝 e 抗原/e 抗体(HBeAg/抗-HBe)的自发性转阴率和逆转率,以及与血清学变化有关的问题。研究对象为慢性乙肝病毒感染(HBV)患者512例(男373,女139),香港华人,年龄1～75岁。无症状携带者331例(64.7%)。其中219例血清丙氨酸转氨酶(ALT)值正常。30%无症状携带者作肝活检证实为慢性肝炎。慢性肝炎112例(21.9%),其中慢性活动性肝炎(CAH)60%,慢性持续性肝炎(CPH)占32%,慢性小叶性肝炎占8%。肝硬化69例(13.5%),急
The authors studied retrospectively and prospectively in patients with chronic hepatitis B virus infection during the past five years. Based on their clinical, biochemical and serological changes, the spontaneous negative rates and reversals of their serum hepatitis B e antigen / e antibodies (HBeAg / anti-HBe) were evaluated, as well as issues related to serological changes. The subjects were 512 patients (373 males and 139 females) with chronic hepatitis B virus infection (HBV), Hong Kong Chinese, aged 1 to 75 years. Asymptomatic carriers of 331 cases (64.7%). Of 219 cases, serum alanine aminotransferase (ALT) values were normal. 30% of asymptomatic carriers confirmed liver biopsy as chronic hepatitis. There were 112 chronic hepatitis patients (21.9%), including 60% of chronic active hepatitis (CAH), 32% of chronic persistent hepatitis (CPH) and 8% of chronic lobular hepatitis. 69 cases of cirrhosis (13.5%), acute