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目的制备布洛芬固体分散体,提高布洛芬的体外溶出速率。方法分别以聚维酮(PVP)、聚乙二醇(PEG)、低取代羟丙基纤维素(L-HPC)为载体,采用溶剂法、熔融法制备布洛芬固体分散体,并测定固体分散体的体外释放情况。结果 PVP、PEG、L-HPC 3种载体对布洛芬均表现出一定的增溶效果,且随着用量的增加溶出速率加快。结论固体分散技术可用于提高布洛芬溶出速率,除PEG、PVP外,L-HPC也可具有一定的增溶效果。
Objective To prepare ibuprofen solid dispersions and increase the in vitro dissolution rate of ibuprofen. Methods Solid dispersions of ibuprofen were prepared by solvent method and melt method respectively with polyvinyl alcohol (PVP), polyethylene glycol (PEG) and low-substituted hydroxypropyl cellulose (L-HPC) as carriers. Dispersion in vitro release. Results Three carriers of PVP, PEG and L-HPC showed some solubilization effect on ibuprofen, and dissolution rate increased with the increase of dosage. Conclusion The solid dispersion technique can be used to increase the dissolution rate of ibuprofen. In addition to PEG and PVP, L-HPC can also have a certain solubilization effect.