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目的探讨急进性肾小球肾炎临床治疗方法。方法选择2009年12月—2011年6月收治的急进性肾小球肾炎患者18例,按照治疗方法分为观察组8例和对照组10例,观察组给予血浆置换治疗,对照组根据患者情况给予甲泼尼龙、环磷酰胺、硫唑嘌呤治疗,根据患者情况调节剂量。全程累积治疗18个月。结果观察组共进行45次治疗,血浆处理量为(3 558.5±1 002.3)ml/次。所有患者均无严重不良反应,随访6个月,18例全部存活。观察组IgG、IgA、IgM、髓过氧化物酶-抗中性粒细胞细胞质抗体、抗肾小球基膜抗体分别为(5.82±2.15)、(2.10±0.51)、(0.67±0.28)g/L、(51.21±21.17)、(12.51±10.50)EU/ml,优于对照组。结论急进性肾小球肾炎患者治疗靶向选定与治疗结果具有相关性,血浆置换术可快速达到治疗效果。
Objective To investigate the clinical treatment of acute glomerulonephritis. Methods 18 patients with acute glomerulonephritis admitted from December 2009 to June 2011 were divided into observation group (n = 8) and control group (n = 10) according to the method of treatment. Patients in the observation group were treated with plasma exchange, and patients in the control group Given methylprednisolone, cyclophosphamide, azathioprine treatment, according to the patient to adjust the dose. The cumulative treatment of 18 months. Results The observation group were treated 45 times, the plasma volume was (3 558.5 ± 1 002.3) ml / time. All patients had no serious adverse reactions, 6 months follow-up, 18 patients all survived. The levels of IgG, IgA, IgM, myeloperoxidase - anti - neutrophil cytoplasmic antibody and anti - glomerular basement membrane antibody were (5.82 ± 2.15), (2.10 ± 0.51) and (0.67 ± 0.28) g / L, (51.21 ± 21.17), (12.51 ± 10.50) EU / ml, respectively, better than the control group. Conclusion The treatment targeting of patients with acute glomerulonephritis is related to the outcome of the treatment, and plasmapheresis can rapidly achieve the therapeutic effect.