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为了探讨山莨菪碱(654-2)对创伤性急性肺损伤(ALI)的防治作用及其可能的机制,观察654-2对创伤性ALI 兔血浆和支气管肺泡灌洗(BALF)中肿瘤坏死因子α(TNF-α)和白细胞介素8(IL-8)含量的影响,同时进行了组织病理学的光镜和电镜检查。结果表明致伤前、后给予654-2,可使创伤性 ALI 兔血浆及 BALF 中的 TNF-α、IL-8明显减少、肺组织损伤程度减轻。说明654-2能降低血浆及 BALF 中 TNF-α、IL-8的含量;654-2通过降低 TNF-α和 IL-8含量减轻或在一定程度上防止创伤性 ALI 的发生和发展。
To investigate the preventive and therapeutic effects of anisodamine (654-2) on traumatic acute lung injury (ALI) and its possible mechanism, we observed the effect of 654-2 on the expression of tumor necrosis factor-α (TNF-α) in plasma and bronchoalveolar lavage (BALF) α (TNF-α) and interleukin-8 (IL-8), and histopathological light and electron microscopy were also performed. The results showed that pretreatment and post-administration of 654-2 could significantly reduce the levels of TNF-α and IL-8 in the plasma and BALF of traumatic ALI rabbits and alleviate the degree of lung injury. These results indicate that 654-2 can reduce the content of TNF-α and IL-8 in plasma and BALF. 654-2 can reduce or partly prevent the occurrence and development of traumatic ALI by decreasing the content of TNF-α and IL-8.