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出血时间延长是米非司酮配伍前列腺素终止早孕最主要的副反应。本研究采用临床试验的方法对350例进行系统观察和分析。结果:该方法终止早孕的阴道出血时间平均12.8±5.9(2～43)天,呈左偏态单峰状分布,峰顶位于第9天。胎囊直径与出血时间呈正相关关系,r=0.169,P<0.01;正常经期>7天组出血时间(14.0±6.2天,n=74)明显长于<7天组(12.5±5.7天,n=276),P<0.05;口服前列腺素组的出血时间(14.1±5.4天,n=99)明显长于阴道给药组(12.3±6.0天,n=251),P<0.01。回归树型分析显示,胎囊大小是影响出血时间最重要的因素。当胎囊直径>12.5mm时出血时间较长。此时如经期<5天则出血时间仍较短,而经期≥5天出血时间较长。后者使用前列腺素阴道栓剂的出血时间短于口服。对这两种前列腺素给药途径可以进一步用胎囊大小判定,胎囊直径超过判定界值时出血时间较长,反之较短。该回归树揭示了上述各危险因素与出血时间延长的关系,并为临床医生确定最佳治疗方案提供了依据。
Bleeding prolonged mifepristone with prostaglandin termination of pregnancy the most important side effects. In this study, 350 cases were systematically observed and analyzed by clinical trial. Results: The mean time of vaginal bleeding in the termination of early pregnancy was 12.8 ± 5.9 (ranged from 2 to 43 days) with a left-skewed unimodal distribution and the peak was located on the 9th day. The diameter of fetal sac was positively correlated with bleeding time (r = 0.169, P <0.01). Bleeding time (14.0 ± 6.2 days, n = 74) in normal menstruation> 7 days was significantly longer than that in less than 7 days (12.5 ± 5.7 days, n = 276), P <0.05; bleeding time in oral prostaglandin group (14.1 ± 5.4 days, n = 99) was significantly longer than that in vaginal administration group (12.3 ± 6.0 days, n = 251) Regression tree analysis showed that fetal capsule size was the most important factor affecting bleeding time. When the fetal sac diameter> 12.5mm longer bleeding time. At this time, such as menstrual <5 days bleeding time is still short, and menstrual bleeding ≥ 5 days longer. The latter use prostaglandin vaginal suppository bleeding time shorter than oral. The two prostaglandin routes of administration can be further used to determine the size of the fetus sac, sac herve leger bandage, sacs louis vuitton, sacs louis vuitton, sacs louis vuitton, sac louis vuitton sac louis vuitton The regression tree reveals the relationship between the above risk factors and prolonged bleeding time, and provides the basis for clinicians to determine the best treatment plan.