论文部分内容阅读
目的探讨重组干扰素α-2b凝胶外用联合阿昔洛韦治疗复发性生殖器疱疹的临床疗效及对患者细胞免疫功能的影响。方法随机将90例复发性生殖器疱疹患者随机分为联合组与对照组,每组45例。对照组予以阿昔洛韦片1次0.2g,1日5次,连服10d。联合组在对照组治疗基础上,局部涂擦重组人干扰素α-2b凝胶,连用10d。结果联合组止疱时间、开始结痂时间、脱痂时间、痊愈时间、1年内复发次数均明显低于对照组(均P<0.05)。治疗前,两组CD3+、CD4+及CD4+/CD8+比值情况基本相似(均P>0.05)。治疗后3个月,联合组CD3+、CD4+及CD4+/CD8+比值均明显高于对照组(均P<0.05)。两组不良反应发生情况,差异无统计学意义(P>0.05)。结论重组人干扰素α-2b凝胶联合阿昔洛韦治疗复发性生殖器疱疹疗效显著,安全、可靠,对复发性生殖器疱疹的细胞免疫功能有一定的增强作用。
Objective To investigate the clinical efficacy of recombinant interferon α-2b gel combined with acyclovir in the treatment of recurrent genital herpes and its effect on cellular immune function. Methods Ninety patients with recurrent genital herpes were randomly divided into combined group and control group, with 45 cases in each group. The control group was given acyclovir tablets 0.2g, on the 1st 5 times, and even served 10d. Combination group in the control group based on the treatment, topical rubbed recombinant human interferon alpha-2b gel for 10d. Results The blistering time, scabbing time, scabbing time, healing time and number of recurrence within one year in the combined group were significantly lower than those in the control group (all P <0.05). Before treatment, the two groups of CD3 +, CD4 + and CD4 + / CD8 + ratio were similar (all P> 0.05). At 3 months after treatment, the ratio of CD3 +, CD4 + and CD4 + / CD8 + in the combination group was significantly higher than that in the control group (all P <0.05). Two groups of adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion The recombinant interferon alfa-2b gel combined with acyclovir is effective, safe and reliable in the treatment of recurrent genital herpes and has a certain enhancement effect on the cellular immune function of recurrent genital herpes.