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氯氮平作为一种有效的抗精神病药物广泛应用于精神科临床,与碳酸锂合并更有利于控制病人的兴奋躁动症状。然而,由于药物间的相互作用机理,可能会促发严重的副反应,现报道碳酸锂合并氯氮平致麻痹性肠梗阻1例如下: H36052男,28岁。诊断偏执型精神分裂症,应用氯氮平治疗,开始氯氮平150mg/日,血浓度181μg/L,因兴奋症状不能控制而合并碳酸锂1500mg/日,氯氮平血浓度升至412μg/日,氯氮平加至450mg/日时,血浓度1244μg/L,患者出现腹胀、腹痛、不排气。查体肠鸣音消失。腹部透视示:肠
Clozapine as an effective antipsychotic is widely used in psychiatric clinics, combined with lithium carbonate is more conducive to the control of patients with agitation symptoms. However, due to the mechanism of drug interactions may trigger serious side effects, it is reported that lithium carbonate combined with clozapine paralytic ileus caused by one case as follows: H36052 male, 28 years old. Diagnosis of paranoid schizophrenia, the application of clozapine treatment, beginning clozapine 150mg / day, blood concentration 181μg / L, due to uncontrollable excitement symptoms and the merger of lithium carbonate 1500mg / day, clozapine blood concentration rose to 412μg / day , Clozapine added to 450mg / day, the blood concentration of 1244μg / L, patients with bloating, abdominal pain, no exhaust. Examination bowel sounds disappear. Abdominal perspective: intestinal