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目的:比较培哚普利和氯沙坦对心力衰竭患者血管内皮功能的影响。方法:78例心力衰竭患者随机分为培哚普利组(38例)和氯沙坦组(40例)。培哚普利组每日口服培哚普利4mg,氯沙坦组每日口服氯沙坦50mg,均连续用药8周。用药前和疗程结束后检测肾素、ATⅡ、醛固酮、ANF、t-PA、PAI、PGF1α、ET-1、NO等。结果:培哚普利治疗心力衰竭的总有效率为73.68%,氯沙坦治疗心力衰竭的总有效率为67.5%。2药均可明显改善血管内皮的分泌功能。结论:培哚普利和氯沙坦在治疗心力衰竭的同时可改善血管内皮功能。
OBJECTIVE: To compare the effects of perindopril and losartan on vascular endothelial function in patients with heart failure. Methods: 78 patients with heart failure were randomly divided into perindopril group (38 cases) and losartan group (40 cases). Perindopril group daily oral administration of perindopril 4mg, losartan group daily oral losartan 50mg, were treated for 8 weeks. Before treatment and after treatment, renin, ATⅡ, aldosterone, ANF, t-PA, PAI, PGF1α, ET-1 and NO were detected. Results: The total effective rate of perindopril in treating heart failure was 73.68%. The total effective rate of losartan in treating heart failure was 67.5%. 2 drugs can significantly improve the secretion of vascular endothelial function. CONCLUSION: Perindopril and losartan improve vascular endothelial function while treating heart failure.