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本研究采用ＡｂｂｏｔｔＡＢＡ一ｌ００型生化自动分析仪对１６例ＤｕｋｅｓＢ期Ｍｉｌｅｓ（腹会阴直肠癌切除）手术标本进行ＬＤＨ、ＡＳＴ（天门冬氨酸转氨酶）、ＡＬＴ（丙氨酸转氨酶）、ＣＫ、ＡＫＰ活性测定，结果表明癌旁３．０ｃｍ以内肠管酶活性升高，与癌组织相近，但与癌旁４．０ｃｍ、５．０ｃｍ肠管及正常肠管差异显著（Ｐ＜０．０１）。同时连续切片检查癌灶肛侧肠管，仅发现１例最远浸润至２．５ｃｍ。结论：３．０ｃｍ以内肠管酶活性升高以非癌浸润引起，很可能是在体内、外致癌因素作用下的原发性改变，认为癌远端肠管切除宜多于４．０ｃｍ。
In this study, 16 specimens of Dukes B Miles surgical specimens were performed for LDH, AST, ALT, alanine aminotransferase, CK, and AKP activity using an Abbott ABA-100 biochemical analyzer. The results showed that the activity of intestinal enzymes was increased within 3.0 cm of the tumor, which was similar to that of cancer tissues, but it was significantly different from the adjacent paracentesis (4.0 cm, 5.0 cm) and normal intestine (P<0.01). At the same time, the anal intestine of the tumor foci was examined by serial sections and only one case was found to be infiltrated to 2.5 cm. Conclusion: The increase of intestinal enzyme activity within 3.0cm is caused by non-cancerous infiltration, which may be the primary change under the influence of the in vivo and external carcinogenic factors. It is considered that the distal part of the cancer should be removed more than 4.0cm.