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用卫生部武汉生物制品研究所生产的三批乙型脑炎减毒活疫苗对湖北省近6万名1—10岁健康儿童进行大面积接种反应观察，发生反应21例，反应率为3．5／万，其中轻度发热率为3．0／万，局部过敏性皮疹率为0．5／万。未发现疫苗引起的异常反应及脑炎或疑似脑炎症状者。对其中1946名1—6岁儿童进行了体温反应和局部红润反应观察3周，体温反应率为0．62—4．4％，以弱反应为主，22例体温中反应者和1例强反应者均为一过性升高，无其它不适，不影响儿童正常活动。观察3天的局部红润反应率为0．96—5．14％，1天时最高，3天时降至正常，以弱反应为主；28例局部中反应者无淋巴结肿大及其它不适，仅1例伴体温弱反应。1例强反应者系过敏所致。本次观察发现此疫苗接种局部反应似与儿童曾接种乙脑疫苗针次有关，接种的针次越多，局部反应率越高。此次观察证明了乙脑减毒活疫苗反应轻微，安全性好，且所有儿童只需接种一针，易于推广使用。
Three hundred batches of Japanese encephalitis live attenuated vaccine produced by the Institute of Biological Products of Ministry of Health of Hubei Province were used to observe the large-scale inoculation of nearly 60,000 healthy children aged 1-10 years in Hubei Province. Twenty-one of them reacted with a response rate of 3. Results 5 / million, of which mild fever rate of 3.0 / million, local allergic rash rate of 0.5 / million. No vaccine-induced abnormalities and encephalitis or suspected encephalitis were found. Among them, 1946 children aged 1-6 years were subjected to body temperature reaction and local rosacea reaction for 3 weeks. The body temperature response rate was 0.62-4.4%. The weak reaction was the main reaction. Among 22 body temperature responders and 1 case strong Responders were transient increase, no other discomfort, does not affect children’s normal activities. The local ruddy response rate of 3 days was 0.96-5.14%, which was the highest at 1 day and dropped to normal at 3 days. The weak reaction was the main reaction in 28 days. There was no lymphadenopathy and other discomfort in 28 cases, only 1 Cases with warm body weak reaction. One case of strong responder caused by allergies. This observation shows that the local vaccination vaccination seems to have been vaccinated with JE vaccine, the more inoculations, the higher the local response rate. The observation shows that JE attenuated live vaccine has mild reaction and good safety, and all children need only take a single dose, which is easy to popularize.