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目的评价沙培林治疗恶性胸腔积液的临床疗效。方法59例恶性胸腔积液患者经皮穿刺置入导管引流胸水后,胸腔内注入沙培林(初次5KE,第二次10KE,第三次15KE)治疗。每次间隔2~3d,总量≤30KE。结果CR30例,率为50.8%(30/59);PR29例,率为49.2%;总有效率(CR+PR)为89.8%(53/59)。NC6例。不良反应为胸痛、发热,患者可耐受。结论沙培林治疗恶性胸腔积液疗效确切,不良反应少,具有临床应用价值。
Objective To evaluate the clinical efficacy of sapirin in the treatment of malignant pleural effusion. Methods 59 patients with malignant pleural effusion were treated with percutaneous drainage of pleural effusion after catheterization. The patients were infused into the pleural space with 5% paclitaxel (the first 5KE, the second 10KE and the third 15KE). Each interval of 2 ~ 3d, the total ≤ 30KE. Results CR 30 cases, the rate was 50.8% (30/59); PR29 cases, the rate was 49.2%; the total effective rate (CR + PR) was 89.8% (53/59). NC6 cases. Adverse reactions to chest pain, fever, patients can tolerate. Conclusion Sapylin treatment of malignant pleural effusion is effective, less adverse reactions, with clinical value.