毛果芸香碱是眼科常用的青光眼治疗剂和缩瞳药。据报道,毛果芸香碱盐类的水溶液不稳定,其稳定性与溶液的 pH 值有密切关系。除了在碱性条件下能迅速被破坏外,在中性或微酸性的情况下,也能缓缓分解变质。因此对毛果芸香碱滴眼液来说,要使药液的 pH 接近中性,减少对眼的刺激,就会使药物的稳定性受到影响。我国药典1963及1977年版都没有收载本品,临床上常用的毛果芸香碱滴眼液大都根据制剂手册等书中的处方配制,一般用磷酸盐作缓冲剂,pH 值调节在6.5左右,没有效期的要求。实际上这样的制剂是不稳定的,我们发现,放置一段时问以后,药物即部 Pilocarpine is a commonly used ophthalmic glaucoma therapeutic agent and miotic agent. It is reported that pilocarpine salts aqueous solution is unstable, its stability and the solution pH is closely related. In addition to being rapidly destroyed under alkaline conditions, it can slowly decompose and degenerate under neutral or slightly acidic conditions. Therefore, pilocarpine eye drops, so that the pH of the liquid near neutral, reduce eye irritation, it will affect the stability of the drug affected. China’s Pharmacopoeia 1963 and 1977 versions are not included in this product, most commonly used pilocarpine eye drops in the preparation of manuals and other books most of the prescription preparation, the general use of phosphate as a buffer, pH adjustment at 6.5 or so, no effective period Claim. In fact, such a formulation is not stable, we found that after placing a period of time, the drug that the Ministry