庆大霉素为细菌静止期的杀菌剂,青霉素为细菌繁殖期杀菌剂,两药联合使用,临床认为不仅可以增强杀菌效力,而且可以降低庆大霉素潜在的毒副反应,故临床合并使用较为普遍。文献报告,青霉素类的β-内酰胺环和庆大霉素的分子,在体外能形成复合物,使庆大霉素失去活性。两药联用又可改善庆大霉素体内的药物动力学性质。本实 Gentamicin for bacterial quiescent bactericides, penicillin for bacterial breeding fungicides, the two drugs used in combination, clinical view not only can enhance the bactericidal effect, but also reduce the potential side effects of gentamicin, it is the clinical use of the merger More common. Literature reports, penicillins β-lactam ring and gentamicin molecules, can form a complex in vitro, so gentamicin loss of activity. Combination of two drugs can improve the pharmacokinetics of gentamicin in vivo. The reality