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目的 观察麒麟丸联合益气养阴中药杞贞滋阴合剂治疗迟发型性腺功能减退(LOH)男性少弱精子症的临床疗效.方法 将64例LOH少弱精子症患者随机分为治疗组和对照组,对照组32例予益气养阴中药杞贞滋阴合剂,治疗组32例予益气养阴中药杞贞滋阴合剂联合麒麟丸.两组疗程均为3个月,评价临床疗效、血清睾酮、精液检查及ADAM量表指标变化情况.结果 治疗组32例(脱落1例),有效率67.74％;对照组32例(脱落2例),有效率43.33％.治疗组治疗后a级精子、(a+b)级精子、精子活动率和精子密度均明显优于治疗前,差异具统计学意义(P＜0.05);对照组(a+b)级精子和精子活动率明显优于治疗前(P＜0.05),但a级精子和精子密度无明显改变,差异无统计学意义(P＞0.05).治疗后治疗组在a级精子、(a+b)级精子、精子活动率和精子密度的改变均明显优于对照组,差异具统计学意义(P＜0.05).症状评分(ADAM表)显示治疗组在体能、血管舒缩和精神心理症状改善方面和对照组大致相当(P＞0.05),而性功能改善方面优于对照组(P＜0.05),睾酮水平方面也有改善.结论 麒麟丸联合益气养阴中药杞贞滋阴合剂治疗LOH男性少弱精子症疗效良好,可以明显提高患者的精子质量和密度,改善LOH相关症状.“,”Objective To observe the clinical effects of Qilin Wan combined with QiZhenZiYin mixture in treating Oligoasthenozoospermia &LOH.Methods Total of 64 patients with Oligoasthenozoospermia &LOH were randomly divided into the treatment group and the control group.The patients in the treatment group were treated with Qilin Wan and QiZhenZiYin Mixture while the patients in the control group were treated with QiZhenZiYin Mixture.And the patients in these two groups were observed for three months.Results All 61 patients completed the experiment and were included in the statistics.The total effective rate of the treatment group was 67.74％;and the control group was 43.33％.The general effect of two groups had significant difference (P＜0.05).The treatment group had significant differences(P＜0.05) in sperm grade a,(a+b),rate of activity and density,as well as the symptom score of AMAS.The treatment group had significant difference (P＜0.05) in sexual function,but it had no significant differences (P＞0.05) in psychological and physical symptoms.The serum total testosterone of two group were ascending,but that of treatment group was obviously ascending (P＜0.05).Conclusion Qilin Wan conbined with QiZhenZiYin Mixture could improve the activity and quality of sperm,as well as clinical symptom and life quality of patients with LOH.