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目的为评价改水降氟对地方性氟中毒的防治效果。方法检测分析了（未改水）病区组、改水病区 组、非病区组 ８～１２岁儿童的尿氟和氟毒性效应指标。结果尿氟均值病区组明显高于改水病区组（ Ｐ <０．０１ ） 和非病区组（Ｐ<０．０１）；尿羟脯氨酸（ＨＯＰ）排泄量均值病区组亦明显高于改水病区组（Ｐ<０．０１）和非病区组（ Ｐ＜０．０１）；改水病区组８～１２岁儿童氟斑牙患病率由卫０年前的８２．４％降至６.４５％，明显低于病区组（Ｐ＜ ０.０１）、斑釉齿指数呈依次递减趋势，病区组，改水病区组、非病区组分别为０．７３，０．０３，０，０２６。血清肌酸磷酸激酶 （ＣＰＫ）活性均值病区组非常明显地高于改水病区组（ Ｐ<０．０１）和非病区组（ Ｐ < ０． ０１）。上述各指标改水病区 组与非病区组比较，均无显著性差异（ Ｐ ＞ ０． ０５）。结论改水降氟后，人群饮用水中摄氟量下降，致使体内氟负 荷减轻，氟毒性效应指标改善，起到了明显的防护作用。
The purpose is to evaluate the effect of changing water and fluoride on prevention and cure of endemic fluorosis. Methods Urinary fluorosis and fluorosis toxicity indexes in children aged 8 ~ 12 years old (non-water-changed), non-water-affected area and non-ward area were detected and analyzed. Results Urine fluoride mean Ward group was significantly higher than that in the water-damaged group (P <0.01) and non-Ward group (P <0.01). Urinary hydroxyproline (HOP) (P <0.01) and non-disease group (P <0.01). The prevalence of dental fluorosis in children aged 8-12 years 82.4%, down to 6.45%, significantly lower than the ward group (P <0.01), the spot glaze tooth index showed a decreasing trend in turn, the ward group, watertight disease group, non-ward group were 0.73, 0.03, 0,026. Serum creatine phosphokinase (CPK) activity was significantly higher in the disease group than in the water-damaged disease group (P <0.01) and in the non-disease group (P <0.01). There was no significant difference between the above indexes in water-affected areas and non-ward areas (P> 0.05). Conclusion After the water is changed into fluoride, the fluoride intake in the drinking water of the population is decreased, which leads to the reduction of fluoride load and the improvement of the index of fluoride toxicity, which plays a significant protective role.