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本文用透射电镜观察肝硬变门脉高压大鼠胃粘膜,发现胃粘膜微循环障碍,毛细血管超微结构异常;上皮细胞和壁细胞超微结构破坏。经汉防己甲素、丹参、心得安治疗后各组的胃粘膜超微结构均趋于正常,上述病理改变消失。证明胃粘膜防御机制的破坏是门脉高压时胃粘膜病变发生的主要原因;汉防己甲素、丹参、心得安对门脉高压时的胃粘膜病变有防治作用。
In this paper, the gastric mucosa of rats with cirrhosis of portal hypertension was observed by transmission electron microscopy. It was found that gastric mucosal microcirculation disorder, abnormal capillary ultrastructure, and ultrastructural damage of epithelial cells and parietal cells. After treatment with tetrandrine, salvia miltiorrhiza, propranolol, the ultrastructure of gastric mucosa in each group tended to be normal, and the above pathological changes disappeared. It is proved that the destruction of the gastric mucosal defense mechanism is the main cause of gastric mucosal lesions during portal hypertension; Tetrandrine, Salvia miltiorrhiza, Propranolol have preventive and therapeutic effects on gastric mucosal lesions at portal hypertension.