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目的探讨+Gz重复暴露对大鼠海马毛细血管超微结构的影响。方法SD大鼠60只,随机分成对照组、+Gz重复暴露后1h、6h、12h、24h和48h组,每组10只。采用动物离心机,建立+Gz引发急性脑缺血模型;常规透射电镜标本制备;对+Gz暴露后不同时间大鼠海马毛细血管超微结构进行观察。结果海马毛细血管超微结构于+Gz重复暴露后1h开始改变,12h改变最重,48h基本恢复正常。结论+Gz重复暴露导致脑缺血,引起毛细血管超微结构的可逆性损伤。
Objective To investigate the effects of repeated + Gz exposure on the ultrastructure of hippocampal capillaries in rats. Methods Sixty Sprague-Dawley rats were randomly divided into control group, Gz + Gz exposure group 1h, 6h, 12h, 24h and 48h, 10 rats in each group. The animal model of acute cerebral ischemia induced by + Gz was established by animal centrifuge. The preparation of conventional TEM specimens was performed. The ultrastructure of hippocampal capillaries was observed at different time after + Gz exposure. Results The ultrastructure of hippocampal capillaries began to change at 1 hour after repeated exposure to + Gz, and changed most rapidly at 12 hours and returned to normal after 48 hours. Conclusions + Gz repeated exposure leads to cerebral ischemia, causing reversible damage of capillary ultrastructure.