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心脏病妇女在用抗凝治疗时不宜妊娠,因为对母亲及胎儿有高度危险性。口服避孕药可能限制抗凝剂在凝血过程中的作用。作者复习一组同时服用避孕药及抗凝剂的心脏病妇女,以确定两者间的作用。197例抗凝治疗病人中,有12例妇女同时服用抗凝剂及避孕药。病者年龄27～44(平均34.5)岁,均无肾病、肝病或高血压病。抗凝治疗指征:瓣膜修复术9例(二尖瓣5例、主动脉瓣1例、同时二尖瓣及主动脉瓣3例),栓塞性二尖瓣病3例。随访共374病人月(平均31.2月/病人)。A期230个月为同时服抗凝剂及避孕药。B期144个月只服抗凝剂。
Heart disease women should not be pregnant with anticoagulant therapy, because of the high risk to mothers and fetuses. Oral contraceptives may limit the role of anticoagulants in the clotting process. The authors review a group of heart-attack women taking both birth control pills and anticoagulants to determine the role of the two. Among the 197 anticoagulant patients, 12 women took both anticoagulants and contraceptives. Patients aged 27 to 44 (average 34.5) years old, no kidney disease, liver disease or hypertension. Anticoagulation therapy indications: valve repair in 9 cases (mitral valve in 5 cases, 1 case of aortic valve, while mitral and aortic valve in 3 cases), embolic mitral valve disease in 3 cases. A total of 374 patients were followed up (mean 31.2 months / patient). A period of 230 months for the same time taking anticoagulants and contraceptives. B period 144 months only anticoagulant.