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在抗癌药物的研究中,微球已成为一种恒释和靶向给药的重要剂型。以白蛋白微球作为药物载体的研究日益广泛。但目前仍然是以加温(110～165℃)使蛋自变性以在植物油或异辛烷乳剂中,进行化学交联的惯用方法制备微球。由于在水中分散微球需加少量的表面活性剂,而表面活性剂能使亲水白蛋白表面与组织间的物理化学反应降低,使药物的作用及其释放受到影响。本文介绍一种制备亲水固体明胶微球的新方法,制备过程如下。交联剂的制备:取戊二醛2ml及甲苯2ml
In anticancer drug research, microspheres have become an important dosage form for constant release and targeted delivery. The research on albumin microspheres as drug carrier is more and more extensive. However, microspheres are still prepared by conventional methods of heating (110-165 ° C) egg self-denaturing in a vegetable oil or isooctane emulsion for chemical crosslinking. Due to the dispersion of microspheres in the water to be added a small amount of surfactant, and surfactant can make the surface of hydrophilic albumin and the physical and chemical reactions between the lower, so that the role of drugs and their release are affected. This article describes a new method for preparing hydrophilic solid gelatin microspheres, prepared as follows. Preparation of Crosslinking Agent: Take 2ml of glutaraldehyde and 2ml of toluene