分化抑制因子-1(inhibitor of differentiation protein 1,Id-1)是Id转录调节蛋白家族成员之一,属于螺旋-环-螺旋蛋白超家族成员。早期对Id-1的研究认为其主要作用是负向调节正常细胞的分化。近年来研究表明,Id-1在多种肿瘤中过表达并通过多条信号通路促进肿瘤的发生,现就Id-1在肿瘤发生中的作用及其作用机制作一综述。 The inhibitor of differentiation protein-1 (Id-1) is a member of the Id transcription regulatory protein family and belongs to the helix-loop-helix superfamily. Early studies of Id-1 suggest that its primary role is to negatively regulate normal cell differentiation. In recent years, studies have shown that, Id-1 in a variety of tumors over-expression and through multiple signaling pathways to promote tumorigenesis, Id-1 in tumorigenesis and its mechanism of action are reviewed.