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应用洋地黄毒甙进行体内外抗肿瘤活性的研究发现,0.1～1.25μg/ml洋地黄毒甙在体外能显著杀伤 HL-60,K562,SMMC-7721.FGC85,SGC-7901,MKN28细胞,并呈剂量呈依赖性,药物作用24h.IC50分别是 0.132,0.182,0.265,0.282,0.498,0.622μg/ml。0.01～1.25μg/ml洋地黄毒甙处理12h,对HL-60和SGC-7901细胞集落形成率有明显的抑制作用,IC50分别是0.056,0.119μg/ml。与5-氟尿嘧啶(200mg/kg·ld_1,ip)合用能使腹水瘤小鼠的生命延长
In vitro and in vivo anti-tumor activity studies with digoxigenin have shown that 0.1 to 1.25 μg/ml of digoxigenin can significantly kill HL-60, K562, SMMC-7721, FGC85, SGC-7901 and MKN28 cells in vitro. In a dose-dependent manner, the drug effect was 24 h. IC50 was 0.132, 0.182, 0.265, 0.282, 0.498, and 0.622 μg/ml, respectively. 0.01 to 1.25μg/ml digoxigenin treatment for 12h, significantly inhibited the colony formation rate of HL-60 and SGC-7901 cells, IC50 were 0.056, 0.119μg/ml. Combined with 5-fluorouracil (200mg/kg·ld_1,ip) can prolong the life of ascites tumor mice